导师姓名：李文娟
科研方向：肿瘤代谢与化学预防；
个人简介：李文娟，女，博士，毕业于首都医科大学,2009年至2014年在美国肯塔基大学和路易斯安那州立大学进行博士后训练。河北大学引进人才，现任职于基础医学院，受聘副教授，2016年获得药理学硕士导师资格。长期以来一直致力于肿瘤发生发展分子机制、肿瘤代谢与化学预防的研究。已在《Cancer Prevention Research》等本领域权威期刊以第一作者发表SCI论文16篇，共发表论文30余篇，主持国家基金委青年基金项目一项，省自然科学基金面上项目两项，省人社厅基金一项，及校内基金两项。指导本科生申请并完成大学生创新创业省级项目四项，并承担生物与分子生物学等7门本科专业课程的教学任务。

二、研究方向
肿瘤发生发展的分子机制。
肿瘤代谢与化学预防的相关研究。
天然提取物在肿瘤发生发展中的作用机制研究

三、科研、教改项目

科研项目
2019年河北省自然科学基金面上项目，项目编号：H2019201084， 2019-2021，在研，主持人。醉茄素A通过IDH1抑制有氧糖酵解并影响肝脏肿瘤发生发展的机制研究

国家青年基金，项目批准号：81502477，2016-2018，已结题，主持人。醉茄素A稳定IDH1及线粒体功能抑制皮肤肿瘤早期发生发展的机制研究

河北省留学人员科技活动项目择优资助项目，项目编号：C2015003021，2016-2018，已结题，主持人。

2015年河北省自然科学基金资助面上项目，项目编号：H2015201119， 2015-2017，已结题，主持人。

学科建设项目，项目编号：2015A1001，2015-2017，已结题，主持人。

河北大学引进人才项目，项目编号：2015-307，2015至今，在研，主持人。

教改项目
2020年河北大学题（卷）库项目，2020年，申请人。

河北大学精品实验重点项目，2018-2019，实时定量PCR检测小鼠肝脏管家基因β-actin，参与。

四、代表性论文
Kaiyue Xu, Chunjing Zhang, Youbo Li, Xin Xi, Lishuang Zheng, Ming Meng, Tongtong Liu, Yunfeng Zhao, Wenjuan Li. Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation. Translational Cancer Research，2019: 8,2449-2460.

Xuemeng Wang, Limin Chang, Xiaojie Lang, Heng An, Yong Wang, Wenjuan Li, Jianglei Qin. Cross-linking induced thermo-responsive self-healable hydrogels with temperature regulated light emission property. Journal of Polymer Research. May 2019: 26,115.

Liye Cao*, Wen-Juan Li*, Ji-Hong Yang, Yu Wang, Zhi-Juan Hua, Dan Liu, Ya-Qing Chen, Hao-Miao Zhang, Rui Zhang, Ji-Sen Zhao, Shu-Jie Cheng, Quan Zhang. Inflammatory cytokine-induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression. Oncology Letters. 2019: 17, 3163-3172.

Xuemeng Wang, Kaiyue Xu, Haicui Yao, Limin Chang, Yong Wang, Wenjuan Li, Youliang Zhao, Jianglei Qin. Temperature-Regulated Aggregation-Induced Emissive Self-Healable Hydrogel for Controlled Drug Delivery. Polymer Chemistry. 2018: 9:5002-5013.

Heng An, Kaiyue Xu, Limin Chang, Yong Wang, Jianglei Qin#, Wenjuan Li#. Thermo-responsive self-healable hydrogels with extremely mild base degradability and bio-compatibility. Polymer. 2018: 147:38-47.

许凯悦，张春晶，李文娟。IDH1在肿瘤发生发展中的作用及其调控机制的研究进展。中国肿瘤生物治疗杂志。2018: 25（6）：573-579.

王林林，岳培林，张鑫，李文娟. 三磷酸腺苷结合盒转运子E1功能及其在疾病中作用的研究进展. 山东医药. 2017；57（12）：101-103.

Wenjuan li, Chunjing Zhang, H Du, V Huang, B Sun, JP Harris, Q Richardson, X Shen, Rong Jin, Guohong Li, CG Kevil, Xin Gu, Runhua Shi, Yunfeng Zhao. Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model. Mol Carcinog. 2016 Nov;55(11):1739-1746. doi: 10.1002/mc.22423. Epub 2015 Oct 16.

Wenjuan Li, Chunjing Zhang, Amy Ren, Tinna Li, Rong Jin, Guohong Li, Xin Gu, Runhua Shi, Yunfeng Zhao. Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation. PLOS ONE, 10(5), e0126459,May 11 2015.

Wenjuan Li, Chunjing Zhang, Jackson K, Shen X, Jin R, Li G, Kevil CG, Gu X, Shi R, Yunfeng Zhao. UCP2 knockout suppresses mouse skin carcinogenesis. Cancer Prev Res, 8(6), 487-491,JUN 2015.

Wenjuan Li, Chunjing Zhang, Runhua Shi, Xin Gu, Yunfeng Zhao. Mitochondrial uncoupling protein 2 promotes skin carcinogenesis. CANCER RESEARCH, 439(74),OCT 1 2014. (Meeting Abstract)

Wenjuan Li, Joan Liu and Yunfeng Zhao. PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells. Molecular Carcinogenesis, 53(5),403-412,MAY 2014.

Wenjuan Li, Joan Liu, Kasey Jackson, Runhua Shi, Yunfeng Zhao. Sensitizing the Therapeutic Efficacy of Taxol with Shikonin in Human Breast Cancer Cells. PLOS ONE, 9(4), e94079,APR 7 2014.

Wenjuan Li, Krystle Nichols, Cherie-Ann Nathan and Yunfeng Zhao. Mitochondrial uncoupling protein 2 is up-regulated in human head and neck, skin, pancreatic, and prostate tumors. Cancer Biomarkers 13(5), 377-383, 24 Dec 2013.

Wenjuan Li and Yunfeng Zhao. Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells. Cancer Sci, 104(2), 143-148,FEB 2013.

Wenjuan Li and Yunfeng Zhao. “Warburg Effect” and Mitochondrial Metabolism in Skin Cancer. J Carcinogene Mutagene, S4, 002,2012.

Delira Robbins, Wenjuan Li, Katie Humphrey and Yunfeng Zhao. Redox factor-1 mediates inflammatory response during tumor promotion in skin epidermal JB6 cells. Scientific Research, 1(3), 19-24,2012.

Xiaoling Guo*, Wenjuan Li*, Qing Wang, and Hsin-Sheng Yang. AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin D1 Expression and Promotes Cell Proliferation. Genes & Cancer, 2011; 2: 818-828. (*These authors contributed equally to this work.)

Haijun Zhang, Wenjuan Li, Michael J. Franklin, and Arkadiusz Z. Dudek. Polymorphisms in DNA Repair Gene XRCC1 and Skin Cancer Risk: A Meta-analysis. ANTICANCER RESEARCH, 2011; 31: 3945-3952.

Hai-Jun Zhang, Wen-Juan Li, Yan-Yan Gu, Shu-Yan Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Jia. p14ARF interacts with E2F factors to form p14ARF-E2F/partner-DNA complexes repressing E2F-dependent transcription. J Cell Biochem, 2010; 109: 693-701.

联系方式：E-mail：lene_li525@163.com